Pepperoni's Pizza - Med Center

8502 Main St Suite D, Houston
(713) 664-5353

Recent Reviews Order Online Reserve

Customers' Favorites

Small Pizza Build Your Own
Pesto Chicken Pizza
Calzone w Pepperoni
BBQ Chicken Calzone
Meatball Parm Sub
Mozzarella Sticks
Pepperoni Pizza
Pepperoni Rolls
Hawaiian Pizza
Marinara Sauce

Menu

Happy Hour (2:00 pm - 5:00 pm)
Cheese Pizza (8IN Small)
Tomato Sauce, Mozzarella and Choose Your Favorite Toppings8IN Small

Appetizers
Pepperoni Rolls
Served with marinara sauce
Mozzarella Sticks
Served with Marinara Sauce
Garlic Bread With Cheese
8" Loaf of bread Served with Marinara Sauce
Garlic Bread
8" Loaf of bread Served with Marinara Sauce

Salads
Caesar-Salad
Crispy Romaine, Shaved Parmesan Cheese, Croutons and Served With Tableside Caesar Dressing
Greek-Salad
Crispy Romaine, Cucumbers, Green Peppers, Red Onions, Kalamata Olives, Pepperoncini, Tomatoes and Feta cheese Served with Oil and Vinegar Dressing Served with Oil Vinegar Dressing
House-Salad
Crispy Romaine, Cucumbers and Tomatoes and Croutons Served With Your choice of Dressing
Napa-Walnut-Salad
Spring Mix, Cheery Tomatoes, Gorgonzola Cheese and Candied Walnuts Served with raspberry Vinaigrette Dressing

Buffalo Wings
Original-Hot-Wings
Crispy Wings Coated with Original Franks Buffalo Hot Sauce
Mild-Wings
Crispy Wings Coated with Original Franks Buffalo Mild Sauce
Jamaican-Jerk-Wings
Crispy Wings Coated with Spicy Jamaican Jerk Sauce
Mango Habanero Wings
Crispy Wings Coated with Spicy, Mango Habanero Sauce
Korean-BBQ-Wings
Crispy Wings Coated with Spicy Korean Barbecue Sauce
Texas-BBQ-Wings
Crispy Wings Coated With Texas Style Original Barbecue Texas
Plain-Wings
Crispy Plain Oven Roasted Wings
Thai-Chili-Wings
Crispy wings coated with spicy sweet and tangy Thai Chili sauce

Pizza
Cheese-Pizza-BYO
Tomato Sauce, Mozzarella and Choose your Favorite Toppings
Athena-pizza
Olive Oil, Mozzarella, Fresh Garlic, Fresh Oregano, Kalamata Olives, Onions, Fresh Tomatoes and Feta Cheese
Barbecue-Chicken-Pizza
Grilled Chicken, Red Onions, Green Peppers and Drizzle Barbecue Sauce On Top
Chicken-Ranchero-Pizza
Alfredo Sauce, Mozzarella, Grilled Chicken, Bacon Served with Ranch Dressing on Side
Classic-Veggie-Pizza
Tomato Sauce, Mozzarella, Fresh Mushrooms, Red Onions, Green Peppers, Fresh Tomatoes, Black and Green Olives
Buffalo-Chicken-Pizza
Franks Hot Sauce, Mozzarella, Grilled Chicken Served with Ranch on Side
Hawaiian-Pizza
Tomato Sauce, Mozzarella, Canadian Bacon, Pineapple and Bacon
Margherita-Pizza
Olive Oil, Mozzarella, Fresh Basil, Fresh Oregano, Fresh Tomatoes and Fresh Mozzarella
Mediterranean-Pizza
Olive Oil, Mozzarella, Sun Dried Tomatoes, Fresh Spinach, Artichoke Hearts, Fresh Garlic and Fresh Tomatoes
Supreme-Pizza
Tomato Sauce, Mozzarella, Pepperoni, Canadian Bacon, Fresh Mushrooms, Italian Sausage, Beef, Red Onions, Green Peppers, Fresh Tomatoes, Black and Green Olives
New-Yorker-Pizza
Extra Tomato sauce, Extra Mozzarella, Extra Pepperoni
Pepperoni's-Special -Pizza
Tomato Sauce, Mozzarella, Pepperoni, Canadian Bacon, Fresh Mushrooms, Green Peppers, Black Olives and Fresh Tomatoes
Pesto-Chicken-Pizza
Pesto Sauce, Mozzarella, Grilled Chicken, Sundried Tomatoes, Fresh Mushrooms, Red Onions and Fresh Tomatoes
Spinaci-Pizza
Alfredo Sauce, Mozzarella, Ricotta, Grilled Chicken, Fresh Spinach
Mango Habanero Pizza
Olive Oil, Fresh Garlic, Mozzarella, Grilled Chicken, Red Onions, Fresh Jalapenos and Drizzle with Mango Habanero Sauce
Korean BBQ Pizza
Olive oil, Fresh Garlic, Mozzarella, Beef, Red Onions, Fresh Jalapenos and Drizzle with Korean BBQ Sauce
Jamaican Jerk Pizza
Olive Oil, Fresh Garlic, Mozzarella Cheese, Grilled Chicken, Pineapple, Fresh Jalapenos and Jamaican Jerk Sauce
Vegan-Lovers-Pizza
Marinara sauce, Vegan Cheese, Plant Based Pepperoni, Fresh Spinach and Fresh Mushrooms

Calzone
Calzone
Tomato sauce, Mozzarella, Ricotta and Choose Two Toppings Served With a marinara On side

Beverages
12 oz Can
Choose from four different flavors
20 oz Soda
Choose from four different flavors
2 Liter
Choose from four different flavors
Pepperonis Root Beer
homemade root beer, made with real sugar
Mexican Soda
Made with real sugar
Pepperonis Lemonade
Fresh homestyle lemonade
Bottle Of Water
cold and crisp water.

Desserts
Chocolate Chip Cookie
Delicious Chocolate Chip Cookie
Chocolate Cake
3 Layers of Gourmet Chocolate Cake
-Strawberry Cheesecake
-Tiramisu
Modern Italian Dessert with Expresso
Cannoli
Italian pastry filled with a sweet, creamy filling
New York Cheesecake
Original NY Cheesecake

Subs and Gyro
Buffalo Chicken
Grilled Chicken, Buffalo Sauce, Mozzarella Served with Ranch on sideFull 8in Sub
Ham And Cheese
Ham, Mozzarella, Mayo, Lettuce and Tomatoes Served with oil and vinegar Full 8in Sub
Grilled Chicken (Full 8in Sub)
Grilled Chicken, Mayo, Onions, Green Peppers, Lettuce, Tomatoes, Oil and VinegarFull 8in Sub
Italian Sub (Full 8in Sub)
Ham, Salami, Mayo, Black Olives, Green Peppers, Onions, Lettuce Tomatoes and Oil and VinegarFull 8in Sub
Pesto Chicken (Full 8in Sub)
Pesto Sauce, Grilled Chicken, Sundried Tomatoes, Goat Cheese, Lettuce Tomatoes and Oil Vinegar Full 8in Sub
Meatball Parm (Full 8in Sub)
Marinara Sauce, Mozzarella, Beef Meatballs and Parmesan CheeseFull 8in Sub
Philly Cheesesteak (Full 8in Sub)
Mayo, Steak, Mozzarella, Onions and Green PeppersFull 8in Sub
Turkey (Full 8in Sub)
Turkey, Mozzarella, Mayo, Black Olives, Green Peppers, Onions, Lettuce, Tomatoes, Oil and VinegarFull 8in Sub

Pasta
Fettucine Alfredo with Garlic Bread (Pasta)
fettuccine pasta , served with Creamy alfredo sauce add grilled chicken as an option.Pasta
Spaghetti with Garlic Bread (Pasta)
Spaghetti pasta served with marinara sauce add meatballs as an optionPasta
Meat Lasagna with Garlic Bread (Pasta)
layers of pasta, parmesan, ricotta mozzarella, and homemade meat saucePasta
Cheese Ravioli with Garlic Bread (Pasta)
Raviolis filled with Italian cheeses Served with Marinara SaucePasta

Sides
Ranch Dressing
Garlic Dipping Sauce
Side Of Marinara
Side Of Pesto Sauce
Side Of Dressing
Gyro Sauce
Rays Spice Topper
Pepperonis Hot Sauce
Side Of Jalapenos
Side of Meatball (1)
Lay's Potato Chips
Side of Banana Peppers
Side Of Alfredo Sauce
Side Of Anchovies

Catering Menu
60 Pcs Wings
100 Pcs Wings
Half Pan Salad
Half Pan Salad w/chicken
Serves 4-6
Full Pan salad
Full Pan Ravioli Marinara
Half Pan Fettuccine Alfredo
Full Pan fettuccini Alfredo
Half Pan Fettuccine Alfredo w/chicken
Full Pan fettuccini Alfredo chicken
Half Pan Spaghetti Marinara
Full pan Spaghetti marinara
Half Pan Spaghetti Marinara with meatballs
Full Pan Spaghetti marinara w/meatballs
Half Pan Meat Lasagna
Layers of pasta, meat sauce and mozzarella, ricotta and parmesan cheese. Serves 6-8 People
Full Pan Meat Lasagna
Layers of pasta, meat sauce and mozzarella, ricotta and parmesan Cheese. Serves 10-15 People

Photos

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Photo credit: google
Photo credit: google
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Photo credit: ubereats
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Recent Reviews

José was so friendly and helpful and reminded me to get set up with the Rewards program. Delicious All The Meats pizza and the Pepperoni Rolls are fire too!!! I found my new local pizza spot!
February 2026
Been to other Pepperonis locations and this one is our favorite. Great pizza every time and excellent service as well. Whenever we take a trip in the med center, we have lunch here.
February 2026
Came here with my parents and it was very nice! I had the Spaghetti and Meatballs here while my parents had the pizza. The people here are super friendly!! I recommend it for anyone passing through☆
February 2026

More Reviews

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Pepperoni's Pizza - Med Center

8502 Main St Suite D, Houston, TX 77025
(713) 664-5353